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Universities, DENSO Testing Biosensor to Detect SARS-CoV-2

Tokai University, Toyohashi University of Technology, Chubu University, and DENSO Corporation have been jointly developing testing equipment to detect SARS-CoV-2 with support from the Japan Agency for Medical Research and Development (AMED).

DensoUniversities and DENSO announced today that the group has succeeded in developing a biosensor based on a new mechanism and detecting SARS-CoV-2.

The group will accelerate the development toward practical application to contribute to the early diagnosis of infectious diseases, which is a key factor in limiting virus’ spread.

To prevent the medical system from being overwhelmed due to viral infectious diseases, it is essential to prevent the spread of viruses by early diagnosis and isolation.

At present, PCR tests and antigen tests are used for the diagnosis of SARS-CoV-2.

However, these tests cannot evaluate “virus infectivity,” which indicates the power of the detected virus to infect. PCR tests are characterized by their high virus detection sensitivity, but the effort of the sample pretreatment process imposes a high workload on medical professionals.

Meanwhile, antigen tests are simple, but the detection accuracy varies. There has been a growing demand for a high-sensitivity and simple detection method to evaluate viral infectiousness.

The universities and DENSO have been developing a biosensor for clinical testing equipment to enable highly sensitive and quick quantitative detection of viral infectivity. Unlike PCR tests and antigen tests, the biosensor detects the spike protein on the virus surface, which triggers infection, by using a semiconductor sensor and aptamer.

The group has succeeded in developing highly sensitive detection of SARS-CoV-2 with high sensitivity by using this technique for the first time in the world.

The semiconductor sensor can quantitatively measure the viral load by using electrical signals. Thus, it is expected to be used to determine the status of infection and confirm the efficacy of treatment with high accuracy.

The goal of the development of the biosensor by the universities and DENSO is to determine the infectivity of SARS-CoV-2 and offer novel tests that have virus detection sensitivity equivalent to that of PCR tests and which is as simple as antigen tests.

The universities and DENSO remain committed to preventing the spread of SARS-CoV-2 infection by harnessing the technologies that have been refined through the project.

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Aishwarya Saxena

A book geek, with creative mind, an electronics degree, and zealous for writing.Creativity is the one thing in her opinion which drove her to enter into editing field. Allured towards south Indian cuisine and culture, love to discover new cultures and their customs. Relishes in discovering new music genres.

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