Yokogawa Electric Corporation has announced that it has developed the SU10 Single Cellome Unit, a device that uses a nanopipette to inject substances such as genes and drugs and aspirate intracellular materials at target locations in individual cells.
Through the development of such solutions, Yokogawa’s life innovation business is fostering the development of an industry centering on the use of smart cells, i.e. finely-designed, expression-controlled biological cells.
Rapid advances in biotechnology are leading to the development of a bioeconomy that is expected to have a wide-ranging impact on fields ranging from agriculture to manufacturing and healthcare.
One segment of this bioeconomy will be the smart cell industry, which will involve the manufacture of high-performance products such as biological medicines and replacements for petroleum-derived products using finely-designed, expression-controlled cellular organisms (smart cells). Smart cells are expected to bring about major changes in the energy and environmental industries as well as such fields as agriculture, manufacturing, and healthcare, and to solve a number of problems facing humanity.
In April 2018, Yokogawa established a Life Innovation Business Headquarters with the goal of promoting well-being for all. In addition to engaging in our existing life science and manufacturing solutions businesses targeting the pharmaceutical and food industries, the headquarters will work with our customers to develop new products and services that make use of Yokogawa’s core measurement, control, and information technologies, and provide one-stop solutions that revolutionize productivity throughout the pharmaceutical and food industry value chain, from basic research to manufacturing, logistics, and services.
- Minimally invasive nanopipette
The SU10 enables the injection of substances such as genes and drugs and the aspiration of intracellular materials at targeted locations in individual cells. In contrast to the micrometer-sized pipettes that are used to perform such tasks, the tip of the nanopipette used in the SU10 has an outer diameter of approximately one hundred nanometers (nm), making it one of the smallest pipettes available for use in the biology research field. The tip of this nanopipette is much smaller than the cells that are analyzed with the SU10, making it minimally invasive and thereby allowing single-cell analyses of living cells.
- Improved efficiency through the automation of analysis
An industry first, the SU10 automates a series of processes, starting with the detection of a cell surface and continuing with the penetration of the cell surface and the injection and aspiration of materials to and from the cell, all operations that up till now had to be performed manually by skilled researchers. With the SU10, injection and aspiration operations can be performed easily on living cells.
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